Antibiotic Drugs

Product Details:

What is Aravon:

• Aravon Injection is used for Nerve cells disease in brain and spinal cord, Death of brain tissues and other conditions.Aravon Injection contains Edaravone as an active ingredient.Aravon Injection works by attenuating - and 6-OHDA-induced dopaminergic neurotoxicity in the brain.Detailed information related to Aravon Injection's uses, composition, dosage, side effects and reviews is listed below

Aravon Injection Uses:

• Aravon Injection is used for the treatment, control, prevention, improvement of the following diseases, conditions and symptoms:Nerve cells disease in brain and spinal cord Death of brain tissues

Aravon Injection- Side-effects :

• The following is a list of possible side-effects that may occur from all constituting ingredients of Aravon Injection. This is not a comprehensive list. These side-effects are possible, but do not always occur. Some of the side-effects may be rare but serious. Consult your doctor if you observe any of the following side-effects, especially if they do not go away.Pneumonia Abnormally low count of platelets Liver disorders Coagulation disorder Acute kidney failure JaundiceIf you notice other side-effects not listed above, contact your doctor for medical advice. You may also report side-effects to your local food and drug administration authority.

Additional Information:

• Pay Mode Terms: T/T (Bank Transfer)

Product Details:

Renodapt- S 360:
Renodapt S 360 tablet is indicated for the treatment of anti transplant rejection, immunosuppressive, prophylaxis of renal or cardiac rejection and other conditions. Renodapt S 360 tablet contains the following active ingredients: mycophenolate mofetil. It is available in tablet form. Biocon manufactures renodapt s 360 tablet.

Uses:
Renodapt S 360 tablet is used in the treatment, control, prevention, & improvement of the following diseases, conditions and symptoms:Anti transplant rejection Immunosuppressive Prophylaxis of renal or cardiac rejection.

Side effects:
The following is a list of possible side effects that may occur from all constituting ingredients of renodapt s 360 tablet. This is not a comprehensive list. These side effects are possible, but do not always occur. Some of the side effects may be rare but serious. Consult your doctor if you observe any of the following side effects, especially if they do not go away.Gastritis Nausea Abnormal blood counts Abdominal pain Increased blood cholesterol Vomiting Low or high blood pressure Confusion Depression Uric acidSkin cancer Diarrhoea Bacterial, fungal and viral infections Urinary tract infection Infection of organs Pneumonia Anemia Agitation Skin infections Respiratory tract infections Reduction in the number of white cells in the blood Possible development of lymphoma Gastrointestinal haemorrhage Perforation Partial or complete absence of hair from areas of the body Acne Rash Baldness Dizziness P ancreatitis Hepatitis Pulmonary fibrosis If you notice other side effects not listed above, contact your doctor for medical advice. You may also report side effects to your local food and drug administration authority.

Precautions:
Before using this drug, inform your doctor about your current list of medications, over the counter products (e.g. vitamins, herbal supplements, etc.), allergies, pre-existing diseases, and current health conditions (e.g. pregnancy, upcoming surgery, etc.). Some health conditions may make you more susceptible to the side effects of the drug. Take as directed by your doctor or follow the direction printed on the product insert. Dosage is based on your condition. Tell your doctor if your condition persists or worsens. Important counseling points are listed below.People having peptic ulcer disease People having severe renal impairment Should not be consumed by patients having gastrointestinal diseases.

Product Details:

Uses:
Nicotex 4 Mg Chewing Gums Cinnamon Is Used In Smoking Addiction.

How It Works:
Nicotex 4 Mg Chewing Gums Cinnamon Is A Stimulant Drug That Acts As An Agonist At Nicotinic Acetylcholine Receptors. These Are Ionotropic Receptors Composed Up Of Five Homomeric Or Heteromeric Subunits. In The Brain, Nicotex 4 Mg Chewing Gums Cinnamon Binds To Nicotinic Acetylcholine Receptors On Dopaminergic Neurons In The Cortico-Limbic Pathways. This Causes The Channel To Open And Allow Conductance Of Multiple Cations Including Sodium, Calcium, And Potassium. This Leads To Depolarization, Which Activates Voltage-Gated Calcium Channels And Allows More Calcium To Enter The Axon Terminal. Calcium Stimulates Vesicle Trafficking Towards The Plasma Membrane And The Release Of Dopamine Into The Synapse. Dopamine Binding To Its Receptors Is Responsible The Euphoric And Addictive Properties Of Nicotex 4 Mg Chewing Gums Cinnamon. Nicotex 4 Mg Chewing Gums Cinnamon Also Binds To Nicotinic Acetylcholine Receptors On The Chromaffin Cells In The Adrenal Medulla. Binding Opens The Ion Channel Allowing Influx Of Sodium, Causing Depolarization Of The Cell, Which Activates Voltage-Gated Calcium Channels. Calcium Triggers The Release Of Epinephrine From Intracellular Vesicles Into The Bloodstream, Which Causes Vasoconstriction, Increased Blood Pressure, Increased Heart Rate, And Increased Blood Sugar.

Common Side Effects:

• Headache, Hiccup, Dizziness, Dry Mouth, Nausea, Esophagitis, Gastritis, Flatulence, Stomatitis (Inflammation Of The Mouth).

Pregnancy Interaction For Nicotex:

• Nicotex 4 Mg Chewing Gums Cinnamon Is Unsafe To Use During Pregnancy.There Is Positive Evidence Of Human Fetal Risk, But The Benefits From Use In Pregnant Women May Be Acceptable Despite The Risk, For Example In Life-Threatening Situations. Please Consult Your Doctor.

Lactation Interaction For Nicotex:

• Nicotex 4 Mg Chewing Gums Cinnamon Is Probably Unsafe To Use During Breastfeeding. Please Consult Your Doctor.

Product Details:

We Are Suppliers Of Yaz Tabletas It Is Used In Contraception, Post Menopausal Osteoporosis (Porous Bones), Hormone Replacement Therapy (Hrt), Failure Of Ovarian Development And Prostate Cancer.

How It Works:
Ethinylestradiol Belongs To A Class Of Medications Called Estrogens (Female Hormones). It Is A Synthetic Form Of The Naturally Occurring Hormone And Helps In Development And Maintenance Of Menstrual Cycle. In Post-Menopausal Women, It Works By Reducing The Post-Menopausal Symptoms And Risk Of Weakening Bones And Bone Fracture.Drospirenone Is Progesterone, And Together With Estradiol, It Can Provide Contraception By Suppressing Release Of Ovum (Eggs) From Your Ovary, And Interfering With Other Mechanisms That Support Occurrence Of Pregnancy. It Suppresses The Natural Progesterone In The Body, And Thereby Helps In Pmdd And Acne. Its Mechanism Of Action In Prevention Of Osteoporosis Is Not Known.

Common Side Effects:
Headache, Vaginal Bleeding, Breast Enlargement, Pelvic Pain, Vomiting, Vaginal Burning Sensation, Nausea, Edema, Abdominal Pain, Genital Itching, Breast Pain, Hair Loss, Weight Gain, Abnormal Hair Growth, Anxiety, Breast Tenderness, Swelling, Altered Libido, Heartburn, Depression, Burning Sensation, Skin Redness, Weight Loss, Skin Rash, Mood Changes, Flatulence, Constipation, Vaginal Spotting, Pain During Periods, Uterine Bleeding , Vaginal Discharge.Adrenal Insufficiency, Rash, Vaginal Discharge, Headache, Dizziness, Back Pain, Increased Appetite, Pain In Extremity, Decreased Libido, Abdominal Distension, Cushing Syndrome, Sleepiness, Vomiting, Nausea, Edema, Abdominal Pain, Abdominal Pain Lower, Breast Pain, Hair Loss, Fatigue, Acne, Hot Flushes, Thrombophlebitis, Diarrhoea, Irregular Menstrual Cycle, Cushingoid Syndrome, Increased Blood Pressure, Depression, Mood Changes, Nervousness, Constipation, Increased Glucose Level In Blood, Breathing Difficulty
 
Alcohol Interaction For Yaz:Taking Ethinyl Estradiol With Alcohol Can Cause Minor Side Effects.

Pregnancy Interaction For Yaz:Yaz Tablet Is Highly Unsafe To Use During Pregnancy.Human And Animal Studies Have Shown Significant Adverse Effects On The Foetus. Please Consult Your Doctor.

Lactation Interaction For Yaz:Yaz Tablet Is Probably Safe To Use During Breastfeeding. Please Consult Your Doctor.

Product Details:

Uses:
Crestor 10 Mg Tablet Is Used In The Treatment Of Increased Cholesterol Levels In Blood, Increased Triglycerides Levels In Blood And Increased Ldl Levels In Blood.

How It Works:
Crestor 10 Mg Tablet Blocks An Enzyme (Hmg-Coa-Reductase) That Is Required In The Body To Make Cholesterol. As A Result, It Lowers The Level Of Cholesterol In The Body.

Common Side Effects:
Musculoskeletal (Bone, Muscle Or Joint) Pain, Allergic Reaction, Headache, Nausea, Dyspepsia, Nasopharyngitis, Increased Liver Enzymes, Increased Creatine Phosphokinase (Cpk) Level In Blood, Diarrhoea, Flatulence, Constipation, Joint Swelling, Increased Glucose Level In Blood.

Food Interaction For Crestor:
It Can Be Taken With Or Without Food, But It Is Better To Take Crestor 10 Mg Tablet At A Fixed Time.Avoid Crestor 10 Mg Tablet With High-Fat Meals Such As Olive Oil, Nuts Seeds (Brazil Nuts), Dark Chocolate, Butter And Meat.

Alcohol Interaction For Crestor:

• Taking Alcohol With Rosuvastatin Increases The Chances Of Liver Dysfunction.

Pregnancy Interaction For Crestor:

• Crestor 10 Mg Tablet Is Highly Unsafe To Use During Pregnancy.Human And Animal Studies Have Shown Significant Adverse Effects On The Foetus. Please Consult Your Doctor.

Lactation Interaction For Crestor:

• Crestor 10 Mg Tablet Is Probably Unsafe To Use During Breastfeeding. Please Consult Your Doctor.

Product Details:

Uses:
Coralan 5 Mg Tablet Is Used In The Treatment Of Angina (chest Pain) And Heart Failure.

How It Works:
Coralan 5 Mg Tablet Lowers The Heart Rate Which, In Turn, Reduces The Oxygen Requirement Of The Heart. As A Result, The Heart Works More Efficiently.

Common Side Effects:
Slow Heart Rate, Headache, Luminous Phenomena (enhanced Brightness), Uncontrolled Blood Pressure.
Food Interaction For Coralan :
It Is Better To Take Coralan 5 Mg Tablet With Food.

Pregnancy Interaction For Coralan:
Coralan 5 Mg Tablet Is Unsafe To Use During Pregnancy.there Is Positive Evidence Of Human Fetal Risk, But The Benefits From Use In Pregnant Women May Be Acceptable Despite The Risk, For Example In Life-threatening Situations. Please Consult Your Doctor.

Lactation Interaction For Coralan:
Coralan 5 Mg Tablet Is Probably Unsafe To Use During Breastfeeding. Please Consult Your Doctor.

Product Details:

Bosentas is the first of a new drug class, an endothelin receptor antagonist. Tracleer® is indicated for the treatment of pulmonary arterial hypertension in patients with who class iii or iv symptoms, to improve exercise ability and decrease the rate of clinical worsening . Active ingredients: bosentan

Uses:

• Bosentas 125 mg tablet is used in adults and children to treat high blood pressure in the vessels that carry blood to the lungs (pulmonary arterial hypertension). It is also used in adults for the treatment of painful and difficult to heal open sores on fingers and toes (digital ulcers).

How it works:

• Bosentas tablet belongs to the class of medicines called endothelin receptor antagonists. It works by stopping the action of a naturally occurring protein called endothelin-1 that causes blood vessels to narrow and prevents normal blood flow in people who have pulmonary arterial hypertension.

Common side effects:

• Abnormal liver function tests, anemia, decreased blood pressure, diarrhoea, fainting, headache, hypersensitivity reaction, indigestion, ankle swelling, fluid retention, limb swelling, flushing, skin redness, tachycardia, heart rate irregular.

Product Details:

How it works:
Cerazette 0.075 mg tablet is a type of the progestogen, a female  hormone, and acts by preventing the egg cell from ripening.

Common side effects:
Adrenal insufficiency, Rash, Vaginal discharge, Headache, Dizziness, Back pain, Increased appetite, Decreased libido, Pain in extremity, Abdominal distension, Cushing syndrome, Sleepiness, Vomiting, Nausea, Edema, Abdominal pain, Abdominal pain lower, Breast pain, Hair loss, Fatigue, Acne, Hot flushes, Thrombophlebitis, Diarrhoea, Irregular menstrual cycle, Cushingoid syndrome, Increased blood pressure, Depression, Mood changes, Nervousness, Constipation, Increased glucose level in blood, Breathing difficulty.

Food Interaction For Cerazette:
It can be taken with or without food, but it is better to take Cerazette 0.075 mg tablet at a fixed time.

Alcohol Interaction For Cerazette:
Takind Desogestrel with alcohol may cause minor drug interactions which may not be clinically relevant in all patients.

Pregnancy Interaction For Cerazette:
Cerazette 0.075 mg tablet is highly unsafe to use during pregnancy.Human and animal studies have shown significant adverse effects on the foetus. Please consult your doctor.

Product Details:

Information for cabgolin:
Cabergoline(0.25mg) :

Uses :
Cabgolin 0.25 mg tablet is used in increased prolactin levels and acromegaly.

How it works :
Cabgolin 0.25 mg tablet treats increased prolactin level (hyperprolactinemia) by decreasing the amount of prolactin in the body which helps in fertility and period problems ( usually caused by not having the right amount of prolactin). Cabgolin 0.25 mg tablet treats acromegaly by decreasing the amount of growth hormone in the body.

Common side effects :
Breathlessness, Headache, Dizziness, Fainting, Vaginal inflammation, Sleepiness, Vomiting, Orthostatic hypotension (sudden lowering of blood pressure on standing), Nasal congestion, Nausea, Dyspepsia, Fatigue, Angina pectoris, Hallucination, Diarrhoea, Vertigo, Sleep disturbance, Confusion, Peripheral edema, Gastritis, Nose bleed, Increased libido.

Food interaction for cabgolin :
It is better to take Cabgolin 0.25 mg tablet with food.

Alcohol interaction for cabgolin :
Taking cabergoline together with alcohol may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating.

Cabgolin 0.25 mg tablet is probably safe to use during pregnancy.Animal studies have shown low or no adverse effect on the foetus, however, there are limited human studies. Please consult your doctor.

Product Details:

Uses:
Progynova 1 Mg Tablet Is Used In Contraception, Post Menopausal Osteoporosis (Porous Bones) And Hormone Replacement Therapy (Hrt).

How It Works:
Progynova 1 Mg Tablet Is A Form Of Estrogen, A Female Hormone Produced By The Ovaries. It Acts By Replacing The Natural Hormone In The Body, When The Latter Is Deficient.

Common Side Effects:
Ankle Swelling, Vaginal Bleeding, Headache, Breast Enlargement, Pelvic Pain, Altered Menstrual Cycle, Vaginal Itching, Vomiting, Nausea, Edema, Abdominal Pain, Genital Itching, Stomach Cramp, Hair Loss, Absence Of Menstrual Periods, Weight Gain, Acne, Abnormal Hair Growth, Anxiety, Breast Tenderness, Difficulty In Wearing Contact Lense, Abdominal Bloating, Weight Loss, Dark Skin Patches, Vaginal Spotting, Change In Appetite, Limb Swelling, Uterine Bleeding , Vaginal Discharge.

Food Interaction For Progynova:

• It Can Be Taken With Or Without Food, But It Is Better To Take Progynova 1 Mg Tablet At A Fixed Time.

Pregnancy Interaction For Progynova:

• Progynova 1 Mg Tablet Is Highly Unsafe To Use During Pregnancy.Human And Animal Studies Have Shown Significant Adverse Effects On The Foetus. Please Consult Your Doctor.

Product Details:

Information For Diane 35 :Ethinyl Estradiol(0.035 Mg)

Uses:
Ethinyl Estradiol Is Used In Contraception, Post Menopausal Osteoporosis (Porous Bones), Hormone Replacement Therapy (Hrt), Failure Of Ovarian Development And Prostate Cancer.

How It Works:
Ethinylestradiol Belongs To A Class Of Medications Called Estrogens (Female Hormones). It Is A Synthetic Form Of The Naturally Occurring Hormone And Helps In Development And Maintenance Of Menstrual Cycle. In Post-Menopausal Women, It Works By Reducing The Post-Menopausal Symptoms And Risk Of Weakening Bones And Bone Fracture.Common Side Effects :Headache, Vaginal Bleeding, Breast Enlargement, Pelvic Pain, Vomiting, Vaginal Burning Sensation, Nausea, Edema, Abdominal Pain, Genital Itching, Breast Pain, Hair Loss, Weight Gain, Abnormal Hair Growth, Anxiety, Breast Tenderness, Swelling, Altered Libido, Heartburn, Depression, Burning Sensation, Skin Redness, Weight Loss, Skin Rash, Mood Changes, Flatulence, Constipation, Vaginal Spotting, Pain During Periods, Uterine Bleeding , Vaginal Discharge.Cyproterone(2 Mg) :Uses :Cyproterone Is Used In The Treatment Of Prostate Cancer And Polycystic Ovary Syndrome (Pcos).How It Works :Cyproterone Blocks The Effect Of The Natural Male Hormones On The Growth Of Prostate Cells. Cyproterone Also Blocks The Undesired Effects Of Androgens In Females Such As Excessive Hair Growth And Acne.

Common Side Effects:
Rash, Dizziness, Decreased Libido, Breast Enlargement In Male, Sleepiness, Weakness, Nausea, Abdominal Pain, Dyspepsia, Weight Gain, Increased Liver Enzymes, Breast Tenderness, Anemia, Depression, Decreased Appetite, Flatulence, Constipation, Hot Flashes.Alcohol Interaction For Diane 35 :Taking Ethinyl Estradiol With Alcohol Can Cause Minor Side Effects.Pregnancy Interaction For Diane 35 :Diane 35 Tablet Is Highly Unsafe To Use During Pregnancy.Human And Animal Studies Have Shown Significant Adverse Effects On The Foetus. Please Consult Your Doctor.

Product Details:

Mederma Scar Gel is clinically shown to improve the color, texture, and overall appearance of scars.It works for many types of scars, including acne scars, surgery scars, and scars from burns, cuts, and other injuries. You can start using Mederma gel as soon as new skin has formed, typically two or more weeks after the injury or surgery. Make sure the scab has come off naturally and any stitches have been removed. On older scars you may start using Mederma immediately. Directions of use :
Mederma Scar Gel should be evenly applied and gently rubbed into the scar once daily for 8 weeks on newer scars and 3-6 months on older scars.

Note : Remember that results take time, so don't get discouraged if you do not notice results right away. Mederma Advanced users start to see noticeable improvement after about 4 weeks of daily usage, with optimum improvement in 8 weeks. Use under medical supervision.

Product Details:

Uses:
Progynova 2 Mg Tablet Is Used In Contraception, Post Menopausal Osteoporosis (Porous Bones) And Hormone Replacement Therapy (Hrt).

How It Works:
Progynova 2 Mg Tablet Is A Form Of Estrogen, A Female Hormone Produced By The Ovaries. It Acts By Replacing The Natural Hormone In The Body, When The Latter Is Deficient.

Common Side Effects:
Ankle Swelling, Vaginal Bleeding, Headache, Breast Enlargement, Pelvic Pain, Altered Menstrual Cycle, Vaginal Itching, Vomiting, Nausea, Edema, Abdominal Pain, Genital Itching, Stomach Cramp, Hair Loss, Absence Of Menstrual Periods, Weight Gain, Acne, Abnormal Hair Growth, Anxiety, Breast Tenderness, Difficulty In Wearing Contact Lense, Abdominal Bloating, Weight Loss, Dark Skin Patches, Vaginal Spotting, Change In Appetite, Limb Swelling, Uterine Bleeding , Vaginal Discharge.

Food Interaction For Progynova:
It Can Be Taken With Or Without Food, But It Is Better To Take Progynova 2 Mg Tablet At A Fixed Time.

Pregnancy Interaction For Progynova:
Progynova 2 Mg Tablet Is Highly Unsafe To Use During Pregnancy.Human And Animal Studies Have Shown Significant Adverse Effects On The Foetus. Please Consult Your Doctor.

Product Details:

Uses :
Alendronic Acid is used in the treatment of post menopausal osteoporosis (porous bones), osteoporosis in men (porous bones) and steroid induced osteoporosis (porous bones)

How it works :
Alendronic Acid inhibits the activity of osteoclasts, cells that causes loss of bone.

Common side effects :
Headache, Abdominal distension, Acid reflux, Abdominal pain, Difficulty in swallowing, Dyspepsia, Flatulence, Musculoskeletal (bone, muscle or joint) pain, Constipation, Diarrhoea, Esophageal ulcer.
Vitamin D3(5600IU)

Uses :
Vitamin D3 is used in the treatment of nutritional deficiencies.
How it works :
Vitamin D3 provides essential nutrients.

Common side effects :
Common Dosage For Fosavance 70 Mg/5600 Iu Tablet

Pregnancy Interaction For Fosavance :
Fosavance 70 mg/5600 iu tablet may be unsafe to use during pregnancy.Animal studies have shown adverse effects on the foetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.

Product Details:

Tacrograf: Tacrograf is an immunosuppressive drug whose main use is after allogeneic organ transplant to reduce the activity of the patient's immune system and so lower the risk of organ rejection. It reduces t-cell and interleukin-2 (il-2) activity. It is also used in a topical preparation in the treatment of severe atopic dermatitis (eczema), severe refractory uveitis after bone marrow transplants, and the skin condition vitiligo. It is a 23-membered macrolide lactone discovered in 1984 from the fermentation broth of a japanese soil sample that contained the bacteria streptomyces tsukubaensis.Indications: prophylaxis of rejection of allogenic liver or kidney transplants.Atopic dermatitis.

Tacrograf tablet uses and benefits:
Tacrograf tablet is used in the treatment, control, prevention, & improvement of the following diseases, conditions and symptoms:Heart transplantation Liver transplantation Kidney or other organs transplantation Skin diseases

Tacrograf tablet side-effects:
The following is a list of possible side effects that may occur from all constituting ingredients of tacrograf tablet. This is not a comprehensive list. These side effects are possible, but do not always occur. Some of the side effects may be rare but serious. Consult your doctor if you observe any of the following side effects, especially if they do not go away.Vascular diseases Changes in liver enzyme levels Cough Decrease in the number of white blood cells Hairless patches on the scalp Excess of watery fluid collecting in the cavities or tissues of the body Nasal congestion Hallucinations Mood changes Abdominal pain Renal impairment Vomiting Indigestion Bloating Muscle pain Insomnia Increased in weight Itching Depression Skin rashes Cholesterol Acne Urge to vomit Diarrhea Tremors Inflammation of the tongue Increased levels of potassium Vision problems Cramps Anxiety Seizures Deficiency of red cells or haemoglobin in the blood Uric acid in the blood Headache Tinnitus Accumulation of gas in the alimentary canal Weakness If you notice other side effects not listed above, contact your doctor for medical advice. You may also report side effects to your local food and drug administration authority.

Tacrograf tablet precautions & how to use:
Before using this drug, inform your doctor about your current list of medications, over the counter products (e.G. Vitamins, herbal supplements, etc.), allergies, pre-existing diseases, and current health conditions (e.G. Pregnancy, upcoming surgery, etc.). Some health conditions may make you more susceptible to the side effects of the drug. Take as directed by your doctor or follow the direction printed on the product insert. Dosage is based on your condition. Tell your doctor if your condition persists or worsens. Important counseling points are listed below.Avoid exposure to the sun Do not drive or operate heavy machinery Take this medication on an empty stomach or 2-3 hours after a meal.

Product Details:

Neukine Injection Uses:

• Neukine Injection is used for the treatment, control, prevention, improvement of the following diseases, conditions and symptoms:
• Risk of infections in patients getting chemotherapy
• Low level of neutrophils
• Hiv infection
• Mobilization of peripheral blood progenitor cells Join Congenital neutropenia
• Idiopathic neutropenia

Product Details:

Luprodex (Leuprolide acetate) 3.75mg inj, manufactured by Bharat serum, is a synthetic nonapeptide, the analog possesses greater potency than the natural hormone. Leuprolide acts as an agonist at pituitary GnRH receptors. By interrupting the normal pulsatile stimulation of, and thus desensitizing, the Gn RH receptors, it indirectly downregulates the secretion of gonadotropins luteinizing hormone (LH) and follicle-stimulating hormone (FSH), leading to hypogonadism and thus a dramatic reduction in estradiol and levels .